# OnCo record hearing-after-platinum-chemotherapy (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/hearing-after-platinum-chemotherapy/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "hearing-after-platinum-chemotherapy" ;
  schema:name "Hearing and tinnitus after platinum chemotherapy"@en ;
  schema:description "Cisplatin kills the hair cells of the inner ear, starting at the high frequencies, and the loss does not come back. In children, sodium thiosulfate given six hours after each dose cut hearing loss from 63 to 33 per cent in one randomised trial and from 56.4 to 28.6 per cent in another. Nothing equivalent is licensed for adults."@en ;
  schema:url <https://onco.cc/technologies/hearing-after-platinum-chemotherapy/> ;
  schema:dateModified "2026-10-02"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Ototoxicity> ;
  schema:citation <https://doi.org/10.1056/NEJMoa1801109>, <https://doi.org/10.1016/S1470-2045(16)30625-8>, <https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=212937>, <https://doi.org/10.1200/JCO.2016.66.8822>, <https://doi.org/10.1016/j.eclinm.2026.103841>, <https://doi.org/10.1001/jamaoncol.2024.1233>, <https://doi.org/10.1097/MAO.0000000000004446>, <https://doi.org/10.1200/OP.22.00710> ;
  onco:status "established" ;
  onco:tag "rejuvenation", "survivorship", "evidence:strong" ;
  onco:related <https://onco.cc/ideas/idea-moon-hearing-protection-cisplatin/> ;
  onco:cancers <https://onco.cc/cancers/testicular/>, <https://onco.cc/cancers/head-and-neck/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/neuroblastoma/>, <https://onco.cc/cancers/osteosarcoma/> ;
  onco:sections <https://onco.cc/fronts/rejuvenation/>, <https://onco.cc/fronts/supportive-care/>, <https://onco.cc/fronts/chemotherapy/> ;
  onco:technologies <https://onco.cc/technologies/survivorship-care-plan/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:drugs <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/sodium-thiosulfate/> ;
  onco:terms <https://onco.cc/terms/late-effects/> ;
  onco:trials <https://onco.cc/trials/nct00652132/>, <https://onco.cc/trials/nct00716976/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-survivorship/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-brock-n-engl-j-med/> .