# OnCo record hedgehog-inhibitor-tolerability (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/hedgehog-inhibitor-tolerability/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "hedgehog-inhibitor-tolerability" ;
  schema:name "Why people stop taking hedgehog inhibitors"@en ;
  schema:alternateName "vismodegib side effects"@en, "sonidegib side effects"@en, "muscle spasms and dysgeusia"@en, "hedgehog inhibitor discontinuation"@en, "hedgehog pathway resistance"@en ;
  schema:description "The pills that shrink advanced basal cell carcinoma cause muscle cramps, loss of taste, hair loss and weight loss in almost everyone who takes them. None of that is dangerous, and most people stop anyway, because the drug has to be taken for years and it takes the pleasure out of eating and moving."@en ;
  schema:url <https://onco.cc/terms/hedgehog-inhibitor-tolerability/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.ejca.2017.08.022>, <https://www.nice.org.uk/guidance/ta489>, <https://doi.org/10.1111/jdv.16446> ;
  onco:cancers <https://onco.cc/cancers/basal-cell-carcinoma/>, <https://onco.cc/cancers/locally-advanced-bcc/>, <https://onco.cc/cancers/skin-cancer/> ;
  onco:technologies <https://onco.cc/technologies/hedgehog-inhibitors/> ;
  onco:targets <https://onco.cc/targets/smoothened/> ;
  onco:drugs <https://onco.cc/drugs/vismodegib/>, <https://onco.cc/drugs/sonidegib/>, <https://onco.cc/drugs/cemiplimab/>, <https://onco.cc/drugs/patidegib/> ;
  onco:pathways <https://onco.cc/pathways/hedgehog/> ;
  onco:terms <https://onco.cc/terms/irae/> ;
  onco:trials <https://onco.cc/trials/stevie/>, <https://onco.cc/trials/vismoneo/>, <https://onco.cc/trials/cemiplimab-advanced-bcc/>, <https://onco.cc/trials/patidegib-gel-gorlin-phase-2/>, <https://onco.cc/trials/erivance/>, <https://onco.cc/trials/bolt/> .