# OnCo record hepatic-dose-adjustment-of-anticancer-drugs (protocol). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/protocols/hepatic-dose-adjustment-of-anticancer-drugs/>
  a schema:MedicalGuideline ;
  onco:kind "protocol" ;
  schema:identifier "hepatic-dose-adjustment-of-anticancer-drugs" ;
  schema:name "Hepatic dose adjustment of anticancer drugs in reduced liver function"@en ;
  schema:alternateName "liver impairment chemotherapy dosing"@en, "hepatic impairment dose reduction"@en, "Child-Pugh dosing"@en, "NCI Organ Dysfunction Working Group criteria"@en, "NCI ODWG"@en, "chemotherapy and raised bilirubin"@en, "liver metastases dose adjustment"@en ;
  schema:description "Many cancer drugs are broken down by the liver, so if your liver is not working well the dose may need lowering or a different drug may be safer. Your liver blood tests are checked before each cycle, and the team follows the drug's own instructions, which grade liver function in one of two ways that do not always agree."@en ;
  schema:url <https://onco.cc/protocols/hepatic-dose-adjustment-of-anticancer-drugs/> ;
  schema:dateModified "2026-11-11"^^xsd:date ;
  onco:related <https://onco.cc/terms/child-pugh/>, <https://onco.cc/protocols/renal-dose-adjustment-of-anticancer-drugs/>, <https://onco.cc/protocols/sact-prescribing-and-pharmacy-verification/> ;
  onco:drugs <https://onco.cc/drugs/ibrutinib/> ;
  onco:terms <https://onco.cc/terms/pharmacokinetics/> .