# OnCo record hepzato (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/hepzato/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "hepzato" ;
  schema:name "Melphalan hepatic delivery system"@en ;
  schema:description "High-dose melphalan pumped through the liver's own blood supply while the blood leaving the liver is filtered, the first approved treatment for uveal melanoma that has spread to the liver."@en ;
  schema:url <https://onco.cc/drugs/hepzato/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1245/s10434-024-15293-x>, <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4f83c8f7-4cc0-4219-88d5-7cfddce91198>, <https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-melphalan-liver-directed-treatment-uveal-melanoma> ;
  onco:status "approved" ;
  onco:modality "Liver-directed chemotherapy with percutaneous hepatic perfusion" ;
  schema:alternateName "Hepzato Kit" ;
  onco:approval "US 2023: Uveal melanoma with unresectable hepatic metastases affecting less than half the liver and no or limited extrahepatic disease" ;
  onco:cancers <https://onco.cc/cancers/uveal-melanoma/> ;
  onco:sections <https://onco.cc/fronts/surgery/>, <https://onco.cc/fronts/chemotherapy/> ;
  onco:companies <https://onco.cc/companies/delcath/> ;
  onco:trials <https://onco.cc/trials/nct02678572/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-zager-ann-surg-oncol/> .