# OnCo record her2-gastric-sequence (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/her2-gastric-sequence/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "her2-gastric-sequence" ;
  schema:name "HER2 sequence in gastric cancer: zanidatamab/trastuzumab + chemo ± PD-1 → T-DXd"@en ;
  schema:description "For HER2-positive stomach cancer, an antibody-plus-chemotherapy first, then Enhertu when it progresses. Both steps now have phase 3 proof."@en ;
  schema:url <https://onco.cc/pairings/her2-gastric-sequence/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05152147>, <https://clinicaltrials.gov/study/NCT04704934> ;
  onco:cancers <https://onco.cc/cancers/gastric/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/zanidatamab/>, <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/pembrolizumab/> ;
  onco:trials <https://onco.cc/trials/herizon-gea-01/>, <https://onco.cc/trials/destiny-gastric04/>, <https://onco.cc/trials/toga/> ;
  onco:pairs <https://onco.cc/drugs/zanidatamab/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/> .