# OnCo record her2-ish-amplified (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/her2-ish-amplified/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "her2-ish-amplified" ;
  schema:name "HER2 ISH amplified (ERBB2 gene amplification)"@en ;
  schema:alternateName "HER2 ISH+"@en, "HER2 FISH positive"@en, "ERBB2 amplification"@en, "HER2 amplified"@en, "HER2/CEP17 ratio >= 2.0"@en, "HER2 gene amplification"@en, "HER2 Dual ISH"@en ;
  schema:description "ISH counts copies of the HER2 gene in each tumour cell. A ratio of 2 or more against the chromosome 17 control, or 6 or more copies per cell, is amplified and HER2-positive whatever the protein stain showed."@en ;
  schema:url <https://onco.cc/biomarkers/her2-ish-amplified/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.2018.77.8738>, <https://www.fda.gov/medical-devices/in-vitro-diagnostics/list-cleared-or-approved-companion-diagnostic-devices-in-vitro-and-imaging-tools> ;
  onco:tag "biomarker", "her2" ;
  onco:related <https://onco.cc/biomarkers/her2-ihc-3-plus/>, <https://onco.cc/biomarkers/her2-ihc-2-plus/> ;
  onco:cancers <https://onco.cc/cancers/breast-her2-positive/>, <https://onco.cc/cancers/gastric-her2-positive/>, <https://onco.cc/cancers/her2-positive-early-breast-cancer/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/pertuzumab/>, <https://onco.cc/drugs/trastuzumab-emtansine/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/her2-testing-assays/> ;
  onco:terms <https://onco.cc/terms/fish/>, <https://onco.cc/terms/gene-amplification/>, <https://onco.cc/terms/her2-positive/> .