# OnCo record her2-positive (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/her2-positive/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "her2-positive" ;
  schema:name "HER2-positive (IHC 3+ or ISH-amplified)"@en ;
  schema:alternateName "HER2-positive"@en, "HER2 positive"@en, "HER2+"@en, "HER2-negative"@en, "HER2 negative"@en, "HER2−"@en, "IHC 3+"@en, "IHC 2+"@en, "HER2 IHC"@en, "HER2-amplified"@en, "HER2 amplification"@en, "ISH-amplified"@en, "HER2 overexpression"@en, "HER2-overexpressing"@en, "HER2-mutant"@en, "HER2 status"@en, "ASCO/CAP"@en ;
  schema:description "A cancer with too much HER2 growth-signal protein, either scored 3+ on the stain or shown to have extra copies of the gene. Once the most aggressive breast cancer subtype, it is now among the most treatable thanks to anti-HER2 drugs."@en ;
  schema:url <https://onco.cc/terms/her2-positive/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/HER2> ;
  schema:citation <https://en.wikipedia.org/wiki/HER2>, <https://www.rcpath.org/resourceLibrary/g148-dataset-for-histopathological-reporting-of-breast-disease-in-surgical-excision-specimens-of-breast-cancer.html>, <https://doi.org/10.1136/jcp-2022-208632> ;
  onco:related <https://onco.cc/terms/her2-low/>, <https://onco.cc/terms/fish/>, <https://onco.cc/terms/hormone-receptor-status/>, <https://onco.cc/terms/ihc/>, <https://onco.cc/terms/her2-testing-uk-breast/> ;
  onco:cancers <https://onco.cc/cancers/breast-her2-positive/>, <https://onco.cc/cancers/gastric/>, <https://onco.cc/cancers/nsclc/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/>, <https://onco.cc/fronts/diagnostics/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/pertuzumab/> ;
  onco:terms <https://onco.cc/terms/her2-testing-uk-breast/>, <https://onco.cc/terms/receptor-conversion-breast/> ;
  onco:trials <https://onco.cc/trials/katherine/>, <https://onco.cc/trials/aphinity/> .