# OnCo record heracles-criteria (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/heracles-criteria/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "heracles-criteria" ;
  schema:name "HERACLES criteria (HER2 in bowel cancer)"@en ;
  schema:alternateName "HERACLES diagnostic criteria"@en, "HER2 scoring in colorectal cancer"@en, "colorectal HER2 criteria"@en, "ERBB2 positivity colorectal"@en ;
  schema:description "Bowel cancer needed its own rule for calling a tumour HER2-positive, because the rules written for breast and stomach cancer did not transfer. The HERACLES criteria are that rule: intense membrane staining in more than half the cells, confirmed by gene amplification, which finds about one in twenty RAS wild-type bowel cancers."@en ;
  schema:url <https://onco.cc/terms/heracles-criteria/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/HER2/neu> ;
  schema:citation <https://doi.org/10.1038/modpathol.2015.98>, <https://www.nice.org.uk/guidance/ng151/chapter/Recommendations> ;
  onco:tag "gi", "colorectal" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/her2-amplified-colorectal/>, <https://onco.cc/cancers/colon-cancer/>, <https://onco.cc/cancers/rectal-cancer/> ;
  onco:technologies <https://onco.cc/technologies/histopathology-ihc/>, <https://onco.cc/technologies/cgp/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:terms <https://onco.cc/terms/extended-ras-testing/>, <https://onco.cc/terms/sidedness/>, <https://onco.cc/terms/tumour-grade/> .