# OnCo record heracles (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/heracles/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "heracles", "NCT03225937" ;
  schema:name "HERACLES"@en ;
  schema:description "HERACLES showed that the breast cancer drugs trastuzumab and lapatinib, used together, could shrink bowel cancers that carry extra copies of the HER2 gene, turning a laboratory prediction into a treatment for this small group of patients."@en ;
  schema:url <https://onco.cc/trials/heracles/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03225937> ;
  onco:status "positive" ;
  onco:tag "subtype-trials" ;
  onco:phase "2" ;
  onco:cancers <https://onco.cc/cancers/her2-amplified-colorectal/>, <https://onco.cc/cancers/colorectal/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/lapatinib/>, <https://onco.cc/drugs/pertuzumab/>, <https://onco.cc/drugs/trastuzumab-emtansine/> ;
  onco:people <https://onco.cc/people/andrea-sartore-bianchi/>, <https://onco.cc/people/salvatore-siena/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-heracles-lancet-oncol-2016/> .