# OnCo record herizon-btc-01 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/herizon-btc-01/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "herizon-btc-01", "NCT04466891" ;
  schema:name "HERIZON-BTC-01"@en ;
  schema:description "The trial behind the first HER2 drug approved for bile duct and gallbladder cancer: zanidatamab shrank tumours in 41 percent of 80 people with HER2-positive disease that had progressed on chemotherapy, and more than half of those enrolled had gallbladder cancer. It led to approvals in the United States, the European Union and the UK, where NICE recommended it in May 2026."@en ;
  schema:url <https://onco.cc/trials/herizon-btc-01/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04466891>, <https://doi.org/10.1016/S1470-2045(23)00242-5>, <https://doi.org/10.1001/jamaoncol.2025.4736>, <https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ZIIHERA%22>, <https://www.nice.org.uk/guidance/ta1153> ;
  onco:status "positive" ;
  onco:phase "2" ;
  onco:related <https://onco.cc/trials/herizon-btc-302/> ;
  onco:cancers <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/cancers/cholangiocarcinoma/>, <https://onco.cc/cancers/intrahepatic-cholangiocarcinoma/>, <https://onco.cc/cancers/extrahepatic-cholangiocarcinoma/>, <https://onco.cc/cancers/biliary-tract-cancer/> ;
  onco:technologies <https://onco.cc/technologies/bispecific-antibody/> ;
  onco:targets <https://onco.cc/targets/her2/> ;
  onco:drugs <https://onco.cc/drugs/zanidatamab/> ;
  onco:companies <https://onco.cc/companies/jazz/>, <https://onco.cc/companies/zymeworks/>, <https://onco.cc/companies/beone/> ;
  onco:institutions <https://onco.cc/institutions/uclh/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-harding-lancet-oncol/>, <https://onco.cc/key-papers/paper-angerilli-her2-gallbladder-extrahepatic-concordance-hum-pathol-2026/> .