# OnCo record hif-vhl (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/hif-vhl/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "hif-vhl" ;
  schema:name "VHL / HIF oxygen sensing"@en ;
  schema:description "The VHL/HIF pathway is how cells sense oxygen (the 2019 Nobel Prize). VHL destroys HIF when oxygen is present. Kidney cancers lose VHL, so HIF-2α is permanently on and drives blood vessel growth and proliferation."@en ;
  schema:url <https://onco.cc/pathways/hif-vhl/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Hypoxia-inducible_factor> ;
  owl:sameAs <http://www.wikidata.org/entity/Q415096> ;
  schema:citation <https://en.wikipedia.org/wiki/Hypoxia-inducible_factor> ;
  onco:cancers <https://onco.cc/cancers/rcc/> ;
  onco:targets <https://onco.cc/targets/hif2a/>, <https://onco.cc/targets/vegf/>, <https://onco.cc/targets/hif1a/> ;
  onco:drugs <https://onco.cc/drugs/belzutifan/> .