# OnCo record hif1a (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/hif1a/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "hif1a" ;
  schema:name "HIF-1α (HIF1A)"@en ;
  schema:alternateName "HIF-1"@en, "HIF-1 alpha"@en, "HIF1"@en, "MOP1"@en, "hypoxia inducible factor 1 subunit alpha"@en, "HIF1A" ;
  schema:description "HIF-1α is the sensor that lets a tumour cope with low oxygen by switching on blood-vessel growth and sugar burning. It has no direct drug yet; belzutifan hits its sibling HIF-2α, and the mTOR inhibitor temsirolimus lowers HIF-1α levels indirectly."@en ;
  schema:url <https://onco.cc/targets/hif1a/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4910>, <https://www.uniprot.org/uniprotkb/Q16665/entry>, <https://www.ncbi.nlm.nih.gov/gene/3091> ;
  onco:tag "wave5-target" ;
  onco:targetClass "transcription" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4910>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100644>, <https://www.uniprot.org/uniprotkb/Q16665/entry>, <https://www.ncbi.nlm.nih.gov/gene/3091> ;
  onco:related <https://onco.cc/drugs/belzutifan/>, <https://onco.cc/drugs/temsirolimus/>, <https://onco.cc/targets/hif2a/>, <https://onco.cc/targets/mtor/>, <https://onco.cc/targets/vegf/> ;
  onco:cancers <https://onco.cc/cancers/rcc/>, <https://onco.cc/cancers/clear-cell-rcc/> ;
  onco:pathways <https://onco.cc/pathways/hif-vhl/>, <https://onco.cc/pathways/angiogenic-switch/>, <https://onco.cc/pathways/cancer-metabolism/>, <https://onco.cc/pathways/renal-cell-carcinoma-signalling/> .