# OnCo record hif2a (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/hif2a/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "hif2a" ;
  schema:name "HIF-2α"@en ;
  schema:description "A master switch that kidney cancer cells leave permanently on when they lose the VHL gene; belzutifan blocks it."@en ;
  schema:url <https://onco.cc/targets/hif2a/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/EPAS1>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3374>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116016>, <https://www.uniprot.org/uniprotkb/Q99814/entry>, <https://www.ncbi.nlm.nih.gov/gene/2034> ;
  owl:sameAs <http://www.wikidata.org/entity/Q17916838> ;
  schema:citation <https://en.wikipedia.org/wiki/EPAS1> ;
  onco:tag "transcription" ;
  schema:alternateName "EPAS1" ;
  onco:targetClass "transcription" ;
  onco:firstDescribed "1997"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/rcc/> ;
  onco:drugs <https://onco.cc/drugs/belzutifan/> ;
  onco:pathways <https://onco.cc/pathways/hif-vhl/>, <https://onco.cc/pathways/renal-cell-carcinoma-signalling/> .