# OnCo record high-potency-payload-synthesis (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/high-potency-payload-synthesis/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "high-potency-payload-synthesis" ;
  schema:name "Payload-linker synthesis (high-potency API)"@en ;
  schema:description "Payload-linker synthesis makes the cytotoxic small molecules inside ADCs (exatecan, MMAE, DM1, PBD dimers), whose occupational exposure limits sit in the nanogram range, in facilities built so a speck of dust cannot harm a worker. A handful of licensed sites such as Lonza and WuXi STA supply them, and their lead times gate hundreds of ADCs in development."@en ;
  schema:url <https://onco.cc/technologies/high-potency-payload-synthesis/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://www.ecfr.gov/current/title-21/chapter-I/subchapter-C/part-211> ;
  onco:status "established" ;
  onco:tag "supporting" ;
  onco:sections <https://onco.cc/fronts/adcs/>, <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/topoisomerase-inhibitors/>, <https://onco.cc/technologies/adc-cdmo-manufacturing/> ;
  onco:companies <https://onco.cc/companies/lonza/>, <https://onco.cc/companies/wuxi-xdc/>, <https://onco.cc/companies/piramal-pharma-solutions/> .