# OnCo record hippo-yap (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/hippo-yap/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "hippo-yap" ;
  schema:name "Hippo-YAP/TAZ"@en ;
  schema:description "The pathway that tells organs when to stop growing. Cancers disable it so YAP and TAZ stay in the nucleus driving growth; in mesothelioma, NF2 loss does exactly that, and the first drugs against the YAP-TEAD switch are in trials."@en ;
  schema:url <https://onco.cc/pathways/hippo-yap/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Hippo_signaling_pathway> ;
  owl:sameAs <http://www.wikidata.org/entity/Q5768379> ;
  schema:citation <https://doi.org/10.1038/s41568-023-00579-1> ;
  onco:tag "mechanism" ;
  onco:cancers <https://onco.cc/cancers/mesothelioma/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/egfr/> ;
  onco:institutions <https://onco.cc/institutions/mgh/>, <https://onco.cc/institutions/mskcc/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/emt/>, <https://onco.cc/pathways/tumor-microenvironment/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-franklin-nat-rev-cancer/> .