# OnCo record histamine-dihydrochloride (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/histamine-dihydrochloride/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "histamine-dihydrochloride" ;
  schema:name "Histamine dihydrochloride"@en ;
  schema:description "Ceplene is a twice-daily injection of histamine given alongside low-dose interleukin-2 as maintenance treatment for adults with acute myeloid leukaemia in first remission, to help immune cells prevent relapse. It is authorised in Europe only."@en ;
  schema:url <https://onco.cc/drugs/histamine-dihydrochloride/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Histamine_dihydrochloride> ;
  schema:citation <https://doi.org/10.1182/blood-2005-10-4073>, <https://www.ema.europa.eu/en/medicines/human/EPAR/ceplene> ;
  onco:status "approved" ;
  onco:tag "ema-list" ;
  onco:modality "Immunomodulator (H2 receptor agonist) given with interleukin-2" ;
  schema:alternateName "Ceplene" ;
  onco:approval "EU 2008: Maintenance with interleukin-2 for adults with AML in first remission (exceptional circumstances)" ;
  onco:related <https://onco.cc/drugs/aldesleukin/> ;
  onco:cancers <https://onco.cc/cancers/aml/> ;
  onco:technologies <https://onco.cc/technologies/cytokine-therapy/> ;
  onco:trials <https://onco.cc/trials/study-0201/> .