# OnCo record histologic-transformation (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/histologic-transformation/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "histologic-transformation" ;
  schema:name "Histologic transformation"@en ;
  schema:description "When a lung adenocarcinoma escapes targeted therapy by turning into a different cell type, usually small-cell."@en ;
  schema:url <https://onco.cc/terms/histologic-transformation/> ;
  schema:dateModified "2026-09-06"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Transdifferentiation> ;
  schema:citation <https://doi.org/10.1126/scitranslmed.3002003> ;
  onco:related <https://onco.cc/terms/neuroendocrine-differentiation/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/sclc/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/>, <https://onco.cc/cancers/prostate-nepc/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/alk/>, <https://onco.cc/targets/tp53/> ;
  onco:terms <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/neuroendocrine-differentiation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-sequist-genotypic-histological-evolution-egfr-resistance-sci-transl-med-2011/>, <https://onco.cc/key-papers/paper-yu-acquired-resistance-rebiopsy-egfr-ccr-2013/>, <https://onco.cc/key-papers/paper-lee-clonal-history-small-cell-transformation-jco-2017/>, <https://onco.cc/key-papers/paper-offin-rb1-tp53-transformation-risk-jto-2019/>, <https://onco.cc/key-papers/paper-marcoux-egfr-small-cell-transformation-outcomes-jco-2019/>, <https://onco.cc/key-papers/paper-epstein-neuroendocrine-prostate-morphologic-classification-ajsp-2014/>, <https://onco.cc/key-papers/paper-beltran-nepc-divergent-evolution-nat-med-2016/>, <https://onco.cc/key-papers/paper-ku-rb1-trp53-lineage-plasticity-science-2017/>, <https://onco.cc/key-papers/paper-mu-sox2-lineage-plasticity-science-2017/> .