# OnCo record histological-response-induction (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/histological-response-induction/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "histological-response-induction" ;
  schema:name "Histological response to induction chemotherapy (osteosarcoma and Ewing sarcoma)"@en ;
  schema:alternateName "histologic response"@en, "histological response"@en, "percentage necrosis"@en, "tumour necrosis after chemotherapy"@en, "Huvos grade"@en, "Huvos grading"@en, "Salzer-Kuntschik grade"@en, "good responder"@en, "poor responder"@en, "good histological response"@en, "poor histological response"@en, "90 percent necrosis"@en, "chemotherapy-induced necrosis"@en ;
  schema:description "After ten weeks of chemotherapy a bone sarcoma is removed and the pathologist maps how much of it is dead; 90 percent or more necrosis (a good response) predicts cure in most children, under 90 percent predicts relapse, but the EURAMOS-1 trial showed that piling more drugs onto poor responders does not fix that."@en ;
  schema:url <https://onco.cc/terms/histological-response-induction/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  onco:related <https://onco.cc/terms/necrosis/>, <https://onco.cc/terms/pcr/>, <https://onco.cc/terms/rcb/>, <https://onco.cc/drugs/methotrexate/>, <https://onco.cc/drugs/doxorubicin/>, <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/ifosfamide/>, <https://onco.cc/drugs/etoposide/>, <https://onco.cc/drugs/vincristine/>, <https://onco.cc/targets/ewsr1-fli1/> ;
  onco:cancers <https://onco.cc/cancers/osteosarcoma/>, <https://onco.cc/cancers/ewing-sarcoma/> .