# OnCo record hormonal-therapy-roadmap (roadmap). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/roadmaps/hormonal-therapy-roadmap/>
  a schema:CreativeWork ;
  onco:kind "roadmap" ;
  schema:identifier "hormonal-therapy-roadmap" ;
  schema:name "Hormonal therapy roadmap: removing the ovaries → tamoxifen → oral degraders switched by a blood test"@en ;
  schema:description "Cutting off the hormones that breast and prostate cancers feed on has kept people alive for decades. The therapy is now moving from blocking the hormone to destroying its receptor, and from waiting for a scan to switching drugs when a blood test sees resistance coming."@en ;
  schema:url <https://onco.cc/roadmaps/hormonal-therapy-roadmap/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:citation <https://www.nejm.org/doi/full/10.1056/NEJMoa2502929>, <https://www.stampedetrial.org/> ;
  onco:related <https://onco.cc/ideas/idea-prev-low-dose-tamoxifen-uptake/>, <https://onco.cc/ideas/idea-acc-cardiometabolic-clinic-hormone-therapy/>, <https://onco.cc/ideas/idea-tr1-response-adapted-dose-reduction/>, <https://onco.cc/ideas/idea-cost-shorter-course-trials/>, <https://onco.cc/ideas/idea-bio1-ctdna-adaptive-tki/>, <https://onco.cc/roadmaps/radiopharma-roadmap/>, <https://onco.cc/roadmaps/cure-paths/>, <https://onco.cc/roadmaps/targeted-therapy-roadmap/>, <https://onco.cc/roadmaps/prostate-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/prostate/> ;
  onco:sections <https://onco.cc/fronts/hormonal/> ;
  onco:technologies <https://onco.cc/technologies/endocrine-therapy/>, <https://onco.cc/technologies/androgen-deprivation/>, <https://onco.cc/technologies/cdk46-inhibitor/>, <https://onco.cc/technologies/protac-degrader/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/acupuncture-hot-flushes/>, <https://onco.cc/technologies/acupuncture-aromatase-inhibitor-arthralgia/>, <https://onco.cc/technologies/cardio-oncology/> ;
  onco:drugs <https://onco.cc/drugs/tamoxifen/>, <https://onco.cc/drugs/letrozole/>, <https://onco.cc/drugs/exemestane/>, <https://onco.cc/drugs/fulvestrant/>, <https://onco.cc/drugs/goserelin/>, <https://onco.cc/drugs/palbociclib/>, <https://onco.cc/drugs/ribociclib/>, <https://onco.cc/drugs/abemaciclib/>, <https://onco.cc/drugs/dalpiciclib/>, <https://onco.cc/drugs/atirmociclib/>, <https://onco.cc/drugs/alpelisib/>, <https://onco.cc/drugs/capivasertib/>, <https://onco.cc/drugs/inavolisib/>, <https://onco.cc/drugs/gedatolisib/>, <https://onco.cc/drugs/everolimus/>, <https://onco.cc/drugs/elacestrant/>, <https://onco.cc/drugs/imlunestrant/>, <https://onco.cc/drugs/camizestrant/>, <https://onco.cc/drugs/giredestrant/>, <https://onco.cc/drugs/vepdegestrant/>, <https://onco.cc/drugs/abiraterone/>, <https://onco.cc/drugs/enzalutamide/>, <https://onco.cc/drugs/apalutamide/>, <https://onco.cc/drugs/darolutamide/>, <https://onco.cc/drugs/relugolix/>, <https://onco.cc/drugs/leuprolide/>, <https://onco.cc/drugs/degarelix/>, <https://onco.cc/drugs/bicalutamide/>, <https://onco.cc/drugs/mevrometostat/>, <https://onco.cc/drugs/breast-cancer-index/>, <https://onco.cc/drugs/fluoroestradiol-f18/> ;
  onco:trials <https://onco.cc/trials/soft-text/>, <https://onco.cc/trials/paloma-2/>, <https://onco.cc/trials/monaleesa-2/>, <https://onco.cc/trials/monarch-3/>, <https://onco.cc/trials/monarche/>, <https://onco.cc/trials/natalee/>, <https://onco.cc/trials/pallas-penelope-b/>, <https://onco.cc/trials/solar-1/>, <https://onco.cc/trials/capitello-291/>, <https://onco.cc/trials/emerald/>, <https://onco.cc/trials/ember-3/>, <https://onco.cc/trials/serena-6/>, <https://onco.cc/trials/veritac-2/>, <https://onco.cc/trials/lidera/>, <https://onco.cc/trials/cambria/>, <https://onco.cc/trials/persevera/>, <https://onco.cc/trials/evera/>, <https://onco.cc/trials/postmonarch/>, <https://onco.cc/trials/fourlight-1/>, <https://onco.cc/trials/chaarted/>, <https://onco.cc/trials/stampede/>, <https://onco.cc/trials/latitude/>, <https://onco.cc/trials/arches/>, <https://onco.cc/trials/arasens/>, <https://onco.cc/trials/peace-1/>, <https://onco.cc/trials/embark/>, <https://onco.cc/trials/propel/>, <https://onco.cc/trials/talapro-2/>, <https://onco.cc/trials/magnitude/>, <https://onco.cc/trials/capitello-281/>, <https://onco.cc/trials/mevpro-1/>, <https://onco.cc/trials/psmafore/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-drug-pricing/>, <https://onco.cc/bottlenecks/b-biomarker-validation/> .