# OnCo record hpk1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/hpk1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "hpk1" ;
  schema:name "HPK1 (MAP4K1)"@en ;
  schema:alternateName "HPK1"@en, "hematopoietic progenitor kinase 1"@en, "mitogen-activated protein kinase kinase kinase kinase 1"@en, "MAP4K1" ;
  schema:description "HPK1 is a brake inside immune cells: it dampens a T cell's response once the cell has recognised its target. Blocking it is meant to let T cells attack a tumour harder, and an HPK1 inhibitor is in an early trial, alone and with a checkpoint antibody."@en ;
  schema:url <https://onco.cc/targets/hpk1/> ;
  schema:dateModified "2026-11-03"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6863>, <https://www.uniprot.org/uniprotkb/Q92918/entry>, <https://www.ncbi.nlm.nih.gov/gene/11184>, <https://doi.org/10.1007/s12026-012-8319-1> ;
  onco:tag "pipeline-gap-target" ;
  onco:targetClass "kinase" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6863>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104814>, <https://www.uniprot.org/uniprotkb/Q92918/entry>, <https://www.ncbi.nlm.nih.gov/gene/11184> ;
  onco:cancers <https://onco.cc/cancers/metastatic-cancer/> ;
  onco:drugs <https://onco.cc/drugs/cfi-402411/> .