# OnCo record hpv-bivalent-vaccine (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/hpv-bivalent-vaccine/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "hpv-bivalent-vaccine" ;
  schema:name "HPV bivalent vaccine (types 16 and 18)"@en ;
  schema:description "Cervarix is a vaccine against HPV types 16 and 18, the two types that cause most cervical cancers, authorised in the EU in 2007 and the US in 2009 after the 18,000-woman PATRICIA trial showed near-complete protection against type-specific precancer. GSK withdrew it from the US in 2016, but it remains WHO-prequalified and used in national programmes, including single-dose schedules."@en ;
  schema:url <https://onco.cc/drugs/hpv-bivalent-vaccine/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cervarix> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Cervarix>, <https://www.cancer.gov/about-cancer/treatment/drugs/recombinant-hpv-bivalent-vaccine>, <https://doi.org/10.1016/S0140-6736(09)61248-4>, <https://www.ema.europa.eu/en/medicines/human/EPAR/cervarix> ;
  onco:status "approved" ;
  onco:tag "nci-list", "prevention" ;
  onco:modality "Recombinant virus-like particle vaccine (adjuvanted)" ;
  schema:alternateName "Cervarix" ;
  onco:approval "EU 2007: Prevention of premalignant cervical lesions and cervical cancer caused by HPV 16 and 18 from age 9 (Cervarix); anal lesions added later", "US 2009: Prevention of cervical cancer and precursor lesions caused by HPV 16 and 18 in females 10 to 25 (discontinued in the US 2016)" ;
  onco:related <https://onco.cc/drugs/gardasil-9/>, <https://onco.cc/drugs/hpv-quadrivalent-vaccine/> ;
  onco:cancers <https://onco.cc/cancers/cervical/> ;
  onco:technologies <https://onco.cc/technologies/hpv-vaccine/>, <https://onco.cc/technologies/interception-vaccination/> ;
  onco:companies <https://onco.cc/companies/gsk/> ;
  onco:trials <https://onco.cc/trials/patricia/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-patricia-paavonen-lancet-2009/> .