# OnCo record hpv-independent-vulvar-cancer (cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/cancers/hpv-independent-vulvar-cancer/>
  a schema:MedicalCondition ;
  onco:kind "cancer" ;
  schema:identifier "hpv-independent-vulvar-cancer" ;
  schema:name "HPV-independent vulvar squamous cell carcinoma (p53-mutant)"@en ;
  schema:alternateName "HPV-negative vulvar cancer"@en, "p53-abnormal vulvar squamous cell carcinoma"@en, "Keratinising vulvar carcinoma"@en, "Vulvar cancer arising from differentiated VIN and lichen sclerosus"@en ;
  schema:description "HPV-independent vulvar cancer is the commoner type of vulvar squamous cell cancer, arising in older women from the chronic skin condition lichen sclerosus rather than from HPV, and marked by faults in the p53 gene. It recurs locally far more often than the HPV type, so treatment centres on complete surgical removal, control of the surrounding skin disease and long follow-up."@en ;
  schema:url <https://onco.cc/cancers/hpv-independent-vulvar-cancer/> ;
  schema:dateModified "2026-09-18"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Vulvar_cancer> ;
  schema:citation <https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1476>, <https://en.wikipedia.org/wiki/Vulvar_cancer> ;
  onco:tag "subtype-page", "gynaecologic" ;
  onco:related <https://onco.cc/cancers/hpv-associated-vulvar-cancer/>, <https://onco.cc/cancers/vulvar/>, <https://onco.cc/cancers/cutaneous-scc/> ;
  onco:technologies <https://onco.cc/technologies/sentinel-node/>, <https://onco.cc/technologies/imrt-igrt/>, <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/precancer-ablation/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/pd1/> ;
  onco:drugs <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/paclitaxel/>, <https://onco.cc/drugs/bevacizumab/>, <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/cemiplimab/> ;
  onco:terms <https://onco.cc/terms/hpv-p16/>, <https://onco.cc/terms/cps/>, <https://onco.cc/terms/lymphadenectomy/>, <https://onco.cc/terms/chemoradiation/> ;
  onco:trials <https://onco.cc/trials/nct05903833/>, <https://onco.cc/trials/nct05932212/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-groinss-v-ii-radiotherapy-vulvar-micrometastases-jco-2021/>, <https://onco.cc/key-papers/paper-groinss-v-sentinel-node-vulvar-cancer-jco-2008/> ;
  onco:pipeline <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/cemiplimab/>, <https://onco.cc/trials/nct05903833/>, <https://onco.cc/trials/nct05932212/> ;
  onco:standardOfCare <https://onco.cc/technologies/precancer-ablation/>, <https://onco.cc/technologies/sentinel-node/>, <https://onco.cc/terms/lymphadenectomy/>, <https://onco.cc/technologies/imrt-igrt/>, <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/technologies/imrt-igrt/>, <https://onco.cc/terms/chemoradiation/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/paclitaxel/>, <https://onco.cc/drugs/bevacizumab/>, <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/trials/nct05903833/>, <https://onco.cc/trials/nct05932212/>, <https://onco.cc/terms/hpv-p16/> .