# OnCo record hrd-genomic-scar-scores (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/hrd-genomic-scar-scores/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "hrd-genomic-scar-scores" ;
  schema:name "HRD genomic scar scores (GIS, LOH, HRDetect)"@en ;
  schema:alternateName "genomic instability score"@en, "GIS"@en, "LOH score"@en, "HRDetect"@en, "genomic scar"@en, "homologous recombination deficiency score"@en ;
  schema:description "A family of sequencing scores that read the scars a broken DNA repair system leaves across a tumour's genome; a high score qualifies ovarian cancer patients for PARP inhibitor maintenance even without a BRCA mutation."@en ;
  schema:url <https://onco.cc/technologies/hrd-genomic-scar-scores/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1910962>, <https://doi.org/10.1038/nm.4292> ;
  onco:status "standard-of-care" ;
  onco:related <https://onco.cc/technologies/stride-dna-break-detection/> ;
  onco:cancers <https://onco.cc/cancers/high-grade-serous-ovarian-cancer/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/pancreatic/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/> ;
  onco:technologies <https://onco.cc/technologies/hrd-testing/>, <https://onco.cc/technologies/rad51-foci-assay/>, <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/wes-wgs/>, <https://onco.cc/technologies/companion-diagnostic/>, <https://onco.cc/technologies/parp-inhibitor/> ;
  onco:targets <https://onco.cc/targets/brca/>, <https://onco.cc/targets/parp/> ;
  onco:drugs <https://onco.cc/drugs/olaparib/>, <https://onco.cc/drugs/niraparib/>, <https://onco.cc/drugs/mychoice-cdx/>, <https://onco.cc/drugs/foundationone-cdx/> ;
  onco:companies <https://onco.cc/companies/myriad-genetics/>, <https://onco.cc/companies/foundation-medicine/> ;
  onco:terms <https://onco.cc/terms/hrd/> ;
  onco:trials <https://onco.cc/trials/paola-1/>, <https://onco.cc/trials/prima/> .