# OnCo record hrd-in-breast-cancer (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/hrd-in-breast-cancer/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "hrd-in-breast-cancer" ;
  schema:name "Homologous recombination deficiency (HRD) in breast cancer"@en ;
  schema:alternateName "HRD score in breast cancer"@en, "HRD in TNBC"@en, "Genomic instability score 42"@en, "HR-deficient triple-negative breast cancer"@en, "BRCAness"@en ;
  schema:description "Homologous recombination deficiency means a tumour cannot mend double-strand DNA breaks properly, most often because BRCA1 or BRCA2 is lost. About seven in ten triple-negative tumours score as deficient, and they respond better to platinum chemotherapy; but unlike ovarian cancer, no breast cancer drug is approved on the basis of an HRD score, only on a germline BRCA result."@en ;
  schema:url <https://onco.cc/terms/hrd-in-breast-cancer/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Homologous_recombination> ;
  schema:citation <https://doi.org/10.1158/1078-0432.ccr-15-2477>, <https://doi.org/10.1093/annonc/mdy460>, <https://doi.org/10.1200/jco.20.02151>, <https://www.nice.org.uk/guidance/ta886>, <https://www.nice.org.uk/guidance/ng101/chapter/Recommendations> ;
  onco:tag "breast", "tnbc" ;
  onco:cancers <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/brca-associated-tnbc/>, <https://onco.cc/cancers/tnbc-early/> ;
  onco:technologies <https://onco.cc/technologies/hrd-testing/>, <https://onco.cc/technologies/platinum/>, <https://onco.cc/technologies/parp-inhibitor/> ;
  onco:targets <https://onco.cc/targets/brca/>, <https://onco.cc/targets/parp/> ;
  onco:drugs <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/olaparib/> ;
  onco:terms <https://onco.cc/terms/hrd/>, <https://onco.cc/terms/germline-vs-somatic/>, <https://onco.cc/terms/pcr/>, <https://onco.cc/terms/rcb/> ;
  onco:trials <https://onco.cc/trials/geparsixto/> .