# OnCo record hydrophilic-next-gen (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/hydrophilic-next-gen/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "hydrophilic-next-gen" ;
  schema:name "Hydrophilic next-generation linkers (TMALIN, Dolaflexin, sulfonyl-pyrimidine, PEG-containing)"@en ;
  schema:alternateName "glucuronide linker"@en, "PEGylated linker"@en, "beta-glucuronidase-cleavable"@en ;
  schema:description "Hydrophilic next-generation linkers have built-in sugars or polyethylene glycol that let ADCs carry more payload without clumping, and they resist efflux pumps."@en ;
  schema:url <https://onco.cc/terms/hydrophilic-next-gen/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/0008-5472.CAN-15-0129> ;
  onco:related <https://onco.cc/terms/efflux-pump/>, <https://onco.cc/terms/dar/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/sacituzumab-tirumotecan/>, <https://onco.cc/drugs/izalontamab-brengitecan/> ;
  onco:terms <https://onco.cc/terms/linker/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-yurkovetskiy-cancer-res/> .