# OnCo record idea-acc-upfront-reduced-dose-trials-frail (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-acc-upfront-reduced-dose-trials-frail/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-acc-upfront-reduced-dose-trials-frail" ;
  schema:name "Upfront reduced-dose regimens tested head-to-head in frail older patients"@en ;
  schema:description "Frail older patients are often given full doses and then have them cut after bad side effects, or are given nothing. Trials should test starting at a lower dose from the beginning."@en ;
  schema:url <https://onco.cc/ideas/idea-acc-upfront-reduced-dose-trials-frail/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/S0140-6736(21)01789-X> ;
  onco:cancers <https://onco.cc/cancers/gastric/>, <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-aging-comorbidity/>, <https://onco.cc/bottlenecks/b-dose-optimisation/>, <https://onco.cc/bottlenecks/b-trial-design/> .