# OnCo record idea-bio1-adaptive-car-antigen-switch (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-adaptive-car-antigen-switch/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-adaptive-car-antigen-switch" ;
  schema:name "Plan the second CAR-T target before the first one is lost"@en ;
  schema:description "Cell therapies fail when the tumour stops showing the marker they were built to find. Preparing an alternative product in advance would let doctors switch quickly."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-adaptive-car-antigen-switch/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1713137> ;
  onco:cancers <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/multiple-myeloma/>, <https://onco.cc/cancers/all-leukemia/> ;
  onco:technologies <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/allogeneic-cell-therapy/>, <https://onco.cc/technologies/mrd-testing/> ;
  onco:targets <https://onco.cc/targets/cd19/>, <https://onco.cc/targets/cd20/>, <https://onco.cc/targets/bcma/>, <https://onco.cc/targets/gprc5d/> ;
  onco:terms <https://onco.cc/terms/mrd/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-manufacturing-cell-therapy/> .