# OnCo record idea-bio1-adaptive-therapy-platform (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-adaptive-therapy-platform/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-adaptive-therapy-platform" ;
  schema:name "A multi-cancer platform trial of adaptive (dose-holiday) therapy"@en ;
  schema:description "Instead of hitting a tumour with the maximum dose until it stops working, adjust the dose to keep the tumour small and let drug-sensitive cells suppress resistant ones. Test this properly across several cancers."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-adaptive-therapy-platform/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://www.nature.com/articles/s41467-017-01968-5> ;
  onco:related <https://onco.cc/ideas/idea-desmoid-intermittent-dosing/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/melanoma/> ;
  onco:institutions <https://onco.cc/institutions/moffitt/> ;
  onco:terms <https://onco.cc/terms/basket-umbrella-platform/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tumor-heterogeneity/>, <https://onco.cc/bottlenecks/b-dose-optimisation/> .