# OnCo record idea-bio1-ai-binders-disordered-regions (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-ai-binders-disordered-regions/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-ai-binders-disordered-regions" ;
  schema:name "AI-designed proteins that grip the floppy parts of cancer drivers"@en ;
  schema:description "MYC, fusion oncoproteins and transcription factors have shapeless, flexible regions that drugs cannot grip. Deep-learning protein design tools such as RFdiffusion may be able to invent binders that clamp them, for use as degradation handles, intrabodies or targeting domains for CAR and bispecific therapies rather than as drugs themselves."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-ai-binders-disordered-regions/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nrc.2017.36> ;
  onco:technologies <https://onco.cc/technologies/ai-drug-design/> ;
  onco:companies <https://onco.cc/companies/isomorphic-labs/>, <https://onco.cc/companies/generate-biomedicines/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-ai-validation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dang-nat-rev-cancer/> .