# OnCo record idea-bio1-antigen-mapping-at-progression (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-antigen-mapping-at-progression/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-antigen-mapping-at-progression" ;
  schema:name "Re-map the tumour's surface proteins before choosing the next antibody drug"@en ;
  schema:description "Antibody drugs need their target to still be present. After one fails, checking which surface markers remain would guide the choice of the next one instead of guessing."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-antigen-mapping-at-progression/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1713137> ;
  onco:related <https://onco.cc/ideas/idea-payload-switching/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/histopathology-ihc/>, <https://onco.cc/technologies/immuno-pet/>, <https://onco.cc/technologies/single-cell-spatial/> ;
  onco:targets <https://onco.cc/targets/her2/>, <https://onco.cc/targets/trop2/>, <https://onco.cc/targets/her3/>, <https://onco.cc/targets/ceacam5/>, <https://onco.cc/targets/b7h3/>, <https://onco.cc/targets/folr1/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-tumor-heterogeneity/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-slamon-her2-breast-ovarian-science-1989/>, <https://onco.cc/key-papers/paper-yarden-sliwkowski-erbb-network-nrmcb-2001/> .