# OnCo record idea-bio1-apobec-inhibitor-adjunct (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-apobec-inhibitor-adjunct/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-apobec-inhibitor-adjunct" ;
  schema:name "Slow the tumour's mutation engine with APOBEC inhibitors during targeted therapy"@en ;
  schema:description "Subsets of lung, bladder and breast cancers carry raised APOBEC enzyme activity that keeps generating new mutations, feeding resistance. Blocking APOBEC3 alongside a targeted drug aims not to kill cells but to slow the rate at which resistant variants arise; the inhibitors are still in discovery."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-apobec-inhibitor-adjunct/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1113205> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/urothelial/> ;
  onco:drugs <https://onco.cc/drugs/osimertinib/> ;
  onco:terms <https://onco.cc/terms/mutational-signature/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tumor-heterogeneity/>, <https://onco.cc/bottlenecks/b-resistance/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-flaura-nejm-2018/>, <https://onco.cc/key-papers/paper-osimertinib-nsclc-n-engl-j-med-2017/>, <https://onco.cc/key-papers/paper-osimertinib-nsclc-n-engl-j-med-2020/> .