# OnCo record idea-bio1-cfrna-plasticity-tracking (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-cfrna-plasticity-tracking/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-cfrna-plasticity-tracking" ;
  schema:name "Detect tumours changing cell type from RNA in the blood"@en ;
  schema:description "Some cancers escape treatment by changing into a different kind of cell that the drug no longer affects. Tumour RNA in blood could show this shift months before a biopsy would."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-cfrna-plasticity-tracking/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1113205> ;
  onco:related <https://onco.cc/roadmaps/prostate-roadmap/>, <https://onco.cc/ideas/idea-prostate-plasticity-surveillance-before-it-is-neuroendocrine/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/sclc/> ;
  onco:technologies <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/rna-seq/> ;
  onco:targets <https://onco.cc/targets/dll3/>, <https://onco.cc/targets/tp53/> ;
  onco:drugs <https://onco.cc/drugs/tarlatamab/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tumor-heterogeneity/>, <https://onco.cc/bottlenecks/b-resistance/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-vogelstein-surfing-p53-network-nature-2000/> .