# OnCo record idea-bio1-clonal-clearance-endpoint (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-clonal-clearance-endpoint/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-clonal-clearance-endpoint" ;
  schema:name "Make clonal clearance, not tumour shrinkage, a trial endpoint"@en ;
  schema:description "A drug that shrinks a tumour by half but leaves the resistant sub-population untouched will fail. Trials should measure whether every sub-population is cleared, not just overall size."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-clonal-clearance-endpoint/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1113205> ;
  onco:technologies <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:terms <https://onco.cc/terms/recist/>, <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/pfs/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tumor-heterogeneity/>, <https://onco.cc/bottlenecks/b-trial-design/> .