# OnCo record idea-bio1-epigenetic-silencing-in-vivo (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-epigenetic-silencing-in-vivo/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-epigenetic-silencing-in-vivo" ;
  schema:name "Switch off an undruggable oncogene permanently with epigenetic editing"@en ;
  schema:description "Instead of blocking a cancer protein, add a chemical off-switch to its gene so the cell stops making it. Early versions of this tool are being tested in other diseases."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-epigenetic-silencing-in-vivo/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nrc.2017.36> ;
  onco:cancers <https://onco.cc/cancers/neuroblastoma/> ;
  onco:technologies <https://onco.cc/technologies/crispr-screens/>, <https://onco.cc/technologies/epigenetic-drugs/>, <https://onco.cc/technologies/methylation-profiling/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dang-nat-rev-cancer/> .