# OnCo record idea-bio1-fusion-tf-degraders (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-fusion-tf-degraders/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-fusion-tf-degraders" ;
  schema:name "Degraders for the fusion proteins that drive childhood sarcomas"@en ;
  schema:description "Some sarcomas in children are caused by two genes fused into one abnormal protein. That protein is the whole disease, but no drug binds it. Destroying it instead of blocking it could work."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-fusion-tf-degraders/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nrc.2017.36> ;
  onco:cancers <https://onco.cc/cancers/sarcoma/> ;
  onco:technologies <https://onco.cc/technologies/protac-degrader/>, <https://onco.cc/technologies/crispr-screens/>, <https://onco.cc/technologies/pdx-models/> ;
  onco:companies <https://onco.cc/companies/c4-therapeutics/> ;
  onco:terms <https://onco.cc/terms/gene-fusion/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-rare-cancers/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dang-nat-rev-cancer/> .