# OnCo record idea-bio1-glue-degrader-atlas (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-glue-degrader-atlas/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-glue-degrader-atlas" ;
  schema:name "Screen glue-like compounds against every cancer cell line and publish it"@en ;
  schema:description "Molecular glue degraders make one protein destroy another, but thalidomide analogues and indisulam were found by luck. A systematic screen of chemical libraries against genetically diverse cancer cell lines, published as an open atlas, would map which of the roughly 600 human E3 ligases can be redirected and against which targets."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-glue-degrader-atlas/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nrc.2017.36> ;
  onco:technologies <https://onco.cc/technologies/protac-degrader/>, <https://onco.cc/technologies/proteomics/> ;
  onco:companies <https://onco.cc/companies/monte-rosa/>, <https://onco.cc/companies/nurix/>, <https://onco.cc/companies/kymera/>, <https://onco.cc/companies/c4-therapeutics/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-ip-collaboration/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dang-nat-rev-cancer/> .