# OnCo record idea-bio1-multicentre-mouse-trials (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-multicentre-mouse-trials/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-multicentre-mouse-trials" ;
  schema:name "Multi-centre randomised animal trials before committing to a human trial"@en ;
  schema:description "A drug that works in one laboratory's mice often fails elsewhere. Running the confirmatory animal study as a randomised, blinded, multi-laboratory trial, as stroke and amyotrophic lateral sclerosis research has done, would catch this before a human trial; oncology has no such standing infrastructure."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-multicentre-mouse-trials/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1093/biostatistics/kxx069> ;
  onco:technologies <https://onco.cc/technologies/pdx-models/> ;
  onco:institutions <https://onco.cc/institutions/nci/>, <https://onco.cc/institutions/cruk/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-preclinical-models/>, <https://onco.cc/bottlenecks/b-reproducibility/>, <https://onco.cc/bottlenecks/b-translational-valley/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-wong-biostatistics/> .