# OnCo record idea-bio1-mutagenesis-blockade-rev1 (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-mutagenesis-blockade-rev1/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-mutagenesis-blockade-rev1" ;
  schema:name "Turn off the error-prone repair that manufactures resistance mutations"@en ;
  schema:description "Under treatment stress, cancer cells switch on sloppy DNA copying that generates the mutations they need to survive. Blocking that machinery could stop resistance being invented."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-mutagenesis-blockade-rev1/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1713137> ;
  onco:pathways <https://onco.cc/pathways/ddr/> ;
  onco:terms <https://onco.cc/terms/mutational-signature/>, <https://onco.cc/terms/resistance/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/> .