# OnCo record idea-bio1-myc-max-molecular-glue (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-myc-max-molecular-glue/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-myc-max-molecular-glue" ;
  schema:name "Molecular glues that break the MYC-MAX partnership"@en ;
  schema:description "MYC is a cancer-driving transcription factor with no drug because it has no binding pocket. A molecular glue or degrader that jams its required partner MAX, or recruits an E3 ligase to the MYC-MAX interface, could switch it off; gluing disordered proteins now has precedent from cereblon-binding drugs."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-myc-max-molecular-glue/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nrc.2017.36> ;
  onco:technologies <https://onco.cc/technologies/protac-degrader/>, <https://onco.cc/technologies/ai-drug-design/> ;
  onco:companies <https://onco.cc/companies/monte-rosa/>, <https://onco.cc/companies/c4-therapeutics/>, <https://onco.cc/companies/kymera/> ;
  onco:terms <https://onco.cc/terms/oncogene-addiction/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dang-nat-rev-cancer/> .