# OnCo record idea-bio1-p53-mutant-reactivator-expansion (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-p53-mutant-reactivator-expansion/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-p53-mutant-reactivator-expansion" ;
  schema:name "Extend p53 reactivation beyond the Y220C mutation"@en ;
  schema:description "One faulty version of the p53 guardian protein can now be repaired by a drug that plugs a hole in it. Systematically hunting for similar holes in other faulty versions could help far more patients."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-p53-mutant-reactivator-expansion/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nrc.2017.36> ;
  onco:technologies <https://onco.cc/technologies/ai-drug-design/> ;
  onco:targets <https://onco.cc/targets/tp53/> ;
  onco:pathways <https://onco.cc/pathways/p53-cell-cycle/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-vogelstein-surfing-p53-network-nature-2000/>, <https://onco.cc/key-papers/paper-dang-nat-rev-cancer/> .