# OnCo record idea-bio1-paralog-synthetic-lethality (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-paralog-synthetic-lethality/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-paralog-synthetic-lethality" ;
  schema:name "Attack the backup copy when a tumour has lost the original gene"@en ;
  schema:description "Tumours often lose one of a pair of near-identical genes. They then depend entirely on the remaining copy, which a drug can block, killing only the cancer."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-paralog-synthetic-lethality/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nrc.2017.36> ;
  onco:related <https://onco.cc/ideas/idea-mtap-prmt5-mesothelioma/> ;
  onco:technologies <https://onco.cc/technologies/crispr-screens/>, <https://onco.cc/technologies/synthetic-lethality-approaches/>, <https://onco.cc/technologies/protac-degrader/> ;
  onco:institutions <https://onco.cc/institutions/broad-institute/>, <https://onco.cc/institutions/icr-london/> ;
  onco:terms <https://onco.cc/terms/synthetic-lethality/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dang-nat-rev-cancer/> .