# OnCo record idea-bio1-pmhc-bispecifics-public-drivers (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-pmhc-bispecifics-public-drivers/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-pmhc-bispecifics-public-drivers" ;
  schema:name "Antibodies that see mutant KRAS and p53 fragments displayed on the cell surface"@en ;
  schema:description "Cells chop up their internal proteins and display the pieces on their surface. That means even undruggable proteins inside the cell can be attacked from outside by the immune system."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-pmhc-bispecifics-public-drivers/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nrc.2017.36> ;
  onco:technologies <https://onco.cc/technologies/t-cell-engager/>, <https://onco.cc/technologies/bispecific-antibody/>, <https://onco.cc/technologies/tcr-t/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/tp53/> ;
  onco:drugs <https://onco.cc/drugs/tebentafusp/> ;
  onco:companies <https://onco.cc/companies/immunocore/>, <https://onco.cc/companies/immatics/>, <https://onco.cc/companies/tscan/> ;
  onco:terms <https://onco.cc/terms/neoantigen/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-immunotherapy-response/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-vogelstein-surfing-p53-network-nature-2000/>, <https://onco.cc/key-papers/paper-dang-nat-rev-cancer/> .