# OnCo record idea-bio1-pp2a-activators (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-pp2a-activators/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-pp2a-activators" ;
  schema:name "Turn a brake back on: drugs that reactivate the PP2A phosphatase"@en ;
  schema:description "Cells have an enzyme, PP2A, that removes the growth signals cancer relies on. Cancers switch it off. Drugs that switch it back on are an unusual and largely untried approach."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-pp2a-activators/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nrc.2017.36> ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:targets <https://onco.cc/targets/kras/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-dang-nat-rev-cancer/>, <https://onco.cc/key-papers/paper-kras-nsclc-n-engl-j-med-2021/>, <https://onco.cc/key-papers/paper-kras-nsclc-cancer-discov-2018/>, <https://onco.cc/key-papers/paper-kras-nsclc-j-clin-oncol-2005/> .