# OnCo record idea-bio1-slfn11-payload-guidance (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-slfn11-payload-guidance/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-slfn11-payload-guidance" ;
  schema:name "Use SLFN11 status to decide which antibody-drug payload to give next"@en ;
  schema:description "A single protein predicts whether a tumour will respond to DNA-damaging drug payloads. Measuring it could stop patients receiving a second drug of the same kind that will not work."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-slfn11-payload-guidance/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1713137> ;
  onco:related <https://onco.cc/ideas/idea-payload-switching/>, <https://onco.cc/ideas/idea-her2-adc-sequencing-payload/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/histopathology-ihc/>, <https://onco.cc/technologies/topoisomerase-inhibitors/> ;
  onco:terms <https://onco.cc/terms/payload/>, <https://onco.cc/terms/adc-sequencing/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-biomarker-validation/> .