# OnCo record idea-bio1-tumour-on-chip-penetration (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-tumour-on-chip-penetration/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-tumour-on-chip-penetration" ;
  schema:name "Tumour-on-a-chip with blood flow to test whether big drugs actually get in"@en ;
  schema:description "Large drugs such as antibody-drug conjugates must cross vessel walls and travel through dense tissue. A chip with flowing channels and human tissue can measure how far they get."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-tumour-on-chip-penetration/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1093/biostatistics/kxx069> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/organoids/>, <https://onco.cc/technologies/radioligand-therapy/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/sacituzumab-govitecan/> ;
  onco:terms <https://onco.cc/terms/payload/>, <https://onco.cc/terms/bystander-effect/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-preclinical-models/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-wong-biostatistics/> .