# OnCo record idea-bio1-upfront-bypass-combination (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio1-upfront-bypass-combination/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio1-upfront-bypass-combination" ;
  schema:name "Add the second drug on day one when the escape route is predictable"@en ;
  schema:description "If most tumours escape a drug by the same back-up route, blocking that route from the start may prevent resistance rather than chase it."@en ;
  schema:url <https://onco.cc/ideas/idea-bio1-upfront-bypass-combination/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1713137> ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/met/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/braf/> ;
  onco:drugs <https://onco.cc/drugs/osimertinib/>, <https://onco.cc/drugs/sotorasib/>, <https://onco.cc/drugs/amivantamab/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:trials <https://onco.cc/trials/adaura/>, <https://onco.cc/trials/flaura/>, <https://onco.cc/trials/flaura2/>, <https://onco.cc/trials/mariposa/>, <https://onco.cc/trials/rtog-0617/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-combination-space/>, <https://onco.cc/bottlenecks/b-dose-optimisation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-flaura-nejm-2018/>, <https://onco.cc/key-papers/paper-egfr-nsclc-lancet-oncol-2012/>, <https://onco.cc/key-papers/paper-egfr-nsclc-n-engl-j-med-2010/> .