# OnCo record idea-bio2-brain-penetrant-glue-degraders (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-brain-penetrant-glue-degraders/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-brain-penetrant-glue-degraders" ;
  schema:name "Design protein degraders small enough to get into the brain"@en ;
  schema:description "New drugs that destroy cancer proteins are usually too big to enter the brain. Making much smaller versions could bring this approach to brain tumours."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-brain-penetrant-glue-degraders/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa043330> ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/> ;
  onco:technologies <https://onco.cc/technologies/protac-degrader/>, <https://onco.cc/technologies/ai-drug-design/> ;
  onco:companies <https://onco.cc/companies/c4-therapeutics/>, <https://onco.cc/companies/kymera/>, <https://onco.cc/companies/monte-rosa/>, <https://onco.cc/companies/nurix/> ;
  onco:terms <https://onco.cc/terms/blood-brain-barrier/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-brain-delivery/>, <https://onco.cc/bottlenecks/b-undruggable-targets/> .