# OnCo record idea-bio2-engineered-bacteria-payloads (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-engineered-bacteria-payloads/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-engineered-bacteria-payloads" ;
  schema:name "Engineered bacteria that live in tumours and manufacture drugs there"@en ;
  schema:description "Some harmless bacteria naturally grow in the low-oxygen core of tumours. Engineering them to produce immune-activating drugs turns them into tiny factories inside the tumour."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-engineered-bacteria-payloads/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamanetworkopen.2019.2535> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/sting-agonist/>, <https://onco.cc/technologies/bcg-and-intravesical-therapy/>, <https://onco.cc/technologies/cytokine-therapy/> ;
  onco:targets <https://onco.cc/targets/cd47/> ;
  onco:drugs <https://onco.cc/drugs/bcg-intravesical/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/>, <https://onco.cc/bottlenecks/b-undruggable-targets/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-haslam-jama-netw-open/>, <https://onco.cc/key-papers/paper-cd47-pancreatic-pharmacol-res-2022/>, <https://onco.cc/key-papers/paper-cd47-colorectal-cancers-basel-2025/>, <https://onco.cc/key-papers/paper-cd47-colorectal-cancer-res-commun-2025/> .