# OnCo record idea-bio2-epigenetic-priming-cold-tumours (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-epigenetic-priming-cold-tumours/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-epigenetic-priming-cold-tumours" ;
  schema:name "Unmask hidden antigens with a short epigenetic course before immunotherapy"@en ;
  schema:description "Low doses of drugs that change how DNA is packaged can make cancer cells display more of what marks them as abnormal, potentially waking up immunotherapy in cold tumours."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-epigenetic-priming-cold-tumours/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamanetworkopen.2019.2535> ;
  onco:related <https://onco.cc/ideas/idea-immunotherapy-mss-crc/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/epigenetic-drugs/>, <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/methylation-profiling/> ;
  onco:targets <https://onco.cc/targets/ezh2/> ;
  onco:drugs <https://onco.cc/drugs/azacitidine/>, <https://onco.cc/drugs/decitabine-cedazuridine/>, <https://onco.cc/drugs/mevrometostat/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/cold-vs-hot/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-immunotherapy-response/>, <https://onco.cc/bottlenecks/b-tme-immunosuppression/>, <https://onco.cc/bottlenecks/b-combination-space/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-haslam-jama-netw-open/>, <https://onco.cc/key-papers/paper-ezh2-colorectal-br-j-cancer-2009/> .