# OnCo record idea-bio2-fus-for-cell-entry (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-bio2-fus-for-cell-entry/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-bio2-fus-for-cell-entry" ;
  schema:name "Open the barrier so engineered immune cells can enter the brain"@en ;
  schema:description "Engineered immune cells given by drip rarely reach brain tumours. Briefly opening the barrier with focused ultrasound at the right moment may let them in."@en ;
  schema:url <https://onco.cc/ideas/idea-bio2-fus-for-cell-entry/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa043330> ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/> ;
  onco:technologies <https://onco.cc/technologies/bbb-focused-ultrasound/>, <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/glioma-car-t/>, <https://onco.cc/technologies/car-nk-macrophage/>, <https://onco.cc/technologies/immuno-pet/> ;
  onco:targets <https://onco.cc/targets/b7h3/>, <https://onco.cc/targets/gd2/> ;
  onco:companies <https://onco.cc/companies/insightec/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-brain-delivery/>, <https://onco.cc/bottlenecks/b-manufacturing-cell-therapy/> .